I love this hiring by the Colts. Chuck Pagano will bring a toughness and change into Indy. He's a defensive mind and is a 3-4 guy which means there are a lot of changes coming. The Colts obviously have a lot of decisions this offseason and other than Peyton Manning, Robert Mathis is a free agent.
If Pagano were to move into a 3-4 like defense, that would make Dwight Freeney and Robert Mathis (if they signed him) outside linebacker pass rushers like James Harrison and Lamaar Woodley. Which would be a pretty good start. They would need to address the defensive line which they would need to find a guy to plug up the middle (Casey Hampton will most likely be available) and two bigger defensive ends.
Now onto Manning, with more and more hirings/ firings I either think 2 things are going to happen. 1. He's released, 2. He retires. Let's not forget that he has a neck injury and Peyton right now, doesn't even know whether he can play or not. The Colts are in a position where they need to rebuild, rather than retool, which probably means Reggie Wayne is gone.